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Medications Known to Contribute to Delirium in Older Adults

Mnemonic: Drug Category Examples of Drugs
A Antiparkinsonian drugs Trihexyphenidyl, Benzatropine, Bromocriptine, Levadopa, Selegiline (deprenyl)
C Corticosteroids Prednisolone
U Urinary incontinence drugs Oxybutinin (Ditropan), Flavoxate (Urispas)
T Theophylline Theophylline
E Emptying drugs (motility drugs) Metoclopramide (Reglan), Prepulsid (Cisapride)
C Cardiovascular drugs (including anti-hypertensives) Digoxin, Quinidine, Methadopa, Reserpine, Beta Blockers (Propanolol - to a less amount), Diuretics, Ace inhibitors (Captopril & Enalapril), Calcium Channel antagonists (Nifedipine, Verapamil & Diltiazem)
H H2 blockers Cimetidine (uncommon on its own but risk with renal impairment), Ranitidine
A Antimicrobials Cephalosporins, Penicillin, Quinolones & others
N N SAIDS Indomethacin, Ibuprofen, Naproxen, as well as * salicylate compounds
G Geropsychiatry drugs
  1. Tricyclic antidepressants (e.g., Amitriptyline, Desipramine - to a , Imipramine, Nortriptyline)
  2. SSRIs- safer but watch if hyponatremia present.
  3. Benzodiazepines (e.g., diazepam)
  4. Antipsychotics (e.g., Haldol, Chlorpromazine, Risperidone
E ENT drugs Antihistamines/decongestants/cough syrups in over-the-counter preparations
I Insomnia Nitrazepam, Flurazepam, Diazepam, Temazepam
N N arcotics Meperdine, Pentazocine (risky)
M Muscle relaxants Cyclobenzaprine (Flexeril), Methocarbamol (Robaxin)
S Seizure drugs Phenytoin, Primidone

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* This is a table noting some examples of possible medications that can contribute to delirium. It is the physiological status of the older adult and the combination of medications, among other factors that increase risk. Therefore: "Watch and Beware".

Reprinted from Clinics in Geriatric Medicine, 14(1), Flaherty, J.H., Commonly prescribed and over-the counter medications: Causes of confussion, pp. 101-125, copyright (1998), with permission from Elsevier.

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